Scientists have created a first-of-its-kind molecular gadget that uses force to control the release of several tiny molecules, which could revolutionize the fields of material engineering and medicine.
The University of Manchester researchers have developed a force-controlled release mechanism that uses natural forces to cause the targeted release of molecules. This technology has the potential to greatly improve medical care and the development of smart materials.
The discovery, which was made public today in the journal Nature, makes use of a cutting-edge method that involves rotaxane, a kind of interlocked molecule.
This part releases functional molecules, such as medications or healing agents, to precisely target the area in need when it is subjected to mechanical strain, such as that seen at an injured or damaged place.
For instance, the location of a tumor.
Additionally, it shows promise for materials with the ability to self-heal in the event of harm, extending their useful lives.
Consider a scuff on a phone’s screen.
According to Guillaume De Bo, an organic chemistry professor at The University of Manchester, forces are present in nature and are essential to many different processes. Our goal was to take advantage of these forces for revolutionary applications, specifically in medicine delivery and material durability.
“Although this is only a proof-of-concept design, we believe that our rotaxane-based approach holds immense potential with far reaching applications — we’re on the brink of some truly remarkable advancements in healthcare and technology.”
Historically, the forceful release of multiple molecules at once has been difficult to regulate. This is typically accomplished through a molecular “tug of war” in which two polymers tug at opposite sides in order to release a single molecule.
With the new method, several cargo molecules are released in response to force application by the sliding of two polymer chains connected to a central ring-like structure that supports the cargo.